Artemis: Depictions of Form and Femininity in Sculpture

Grecian sculpture has been the subject of investigation for centuries. More recently, however, emphasis in the field of Art History on the politics of gender and sexuality portrayal have opened new avenues for investigation of those old statues. In depicting gender, Ancient Greek statuary can veer towards the non-binary, with the most striking examples being works depicting Hermaphroditos and ‘his’ bodily form. Yet even within the binary, there are complications. Depictions of the goddess Artemis are chief among these complications of the binary, with even more contradiction, subtext, and varied interpretation than representations of Amazons. The numerous ways Artemis has been portrayed over the years highlight her multifarious aspects, but often paint a contradictory portrait of her femininity. Is she the wild mother? The asexual huntress? Or is she a tempting virgin, whose purity is at risk? Depictions of her in sculptural form, deliberately composed, offer answers. Though as separate depictions they sometimes contradict one another, as a whole, they reveal just how Artemis the female was thought of

Paintings of War, Museums of Memory

This paper examines the artists sent to the Western Front under Britain’s official war artists initiative. The government sought to utilize artwork for propagandistic purposes, and to foster emotional connection between civilian and soldier. However, the growth of the initiative to include some ninety artists complicated this. The experiences of the artists and the truths revealed to them by the conflict were vastly different, and examination of them as a whole does little to elucidate the character of the war itself. What this paper seeks to do, therefore, is examine three artists - Sir William Orpen, Lieutenant Paul Nash, and C.R.W. Nevinson – as individuals. In moving away from aggregated narratives and comparing this small group, the importance of subjectivity in memory and representation becomes clear. By returning individuality to a crowded, multitudinous narrative, war can be seen as it truly is: a unique experience for all involved

Captive Body, Free Mind: Euphrosinia Kersnovskaia, the Gulag, and Art Under Oppression

This paper examines the art of Euphrosinia Kersnovskaia (1907-1994) as it relates to both the larger experience and narrative of the Soviet Gulag and to the survival of the artist. Larger trends of art made under oppression are used to find reason for such seemingly insignificant acts, and art therapy frameworks provide analytical bases for approach. By looking at such deeply subjective forms of memory and its transcription, individuality and humanity is returned to an inhuman penal system

Experience, Emotion, and Emoting: Jack Peirs and the Aftermath of Loos

An investigation into the personal letters of one man on the Western Front, this paper seeks to uncover some of the complexities of emotion and emoting within British societal narratives of the First World War. Conceptions of masculinity and stoicism imposed limitations on soldierly expression, forcing them to abide by preordained \u27scripts\u27 to continually qualify as men. The difficulty lay in finding ways to cope emotionally with their surroundings while still playing their \u27roles\u27. By looking closely at the words and coping mechanisms of one man, Lieutenant-Colonel H.J.C. Peirs, in the aftermath of the Battle of Loos, this paper attempts to frame the emotive techniques of soldiers struggling to find peace within while remaining a \u27man\u27 without

Blue-and-White Wonder: Ming Dynasty Porcelain Plate

This authentic Ming Dynasty (1368-1644) plate is a prime example of early export porcelain, a luminous substance that enthralled European collectors. The generous gift of Joyce P. Bishop in honor of her daughter, Kimberly Bishop Connors, Ming Dynasty Blue-and-White Plate is on loan from the Reeves Collection at Washington and Lee University in Lexington, Virginia. The plate itself is approximately 7.75 inches (20 cm) in diameter, and appears much deeper from the bottom than it does from the top. Gradually sloping forms are what make the dish so deceptively shallow. In fact, from the reverse, it appears closer in shape to a soup-plate. The lip of the bowl is shaped in a barbed pattern, with gentle waves and peaks creating a textured edge. The whole of the plate is evenly shaped, indicating it was shaped on a potter’s wheel and not by hand. [excerpt

Experimental versus theoretical log D_7.4, pK_a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances

The misuse of benzodiazepines as new psychoactive substances is an increasing problem around the world. Basic physicochemical and pharmacokinetic data is required on these substances in order to interpret and predict their effects upon humans. Experimental log D7.4, pKa and plasma protein binding values were determined for 11 benzodiazepines that have recently appeared as new psychoactive substances (3‐hydroxyphenazepam, 4’‐chlorodiazepam, desalkylflurazepam, deschloroetizolam, diclazepam, etizolam, flubromazepam, flubromazolam, meclonazepam, phenazepam and pyrazolam) and compared with values generated by various software packages (ACD/I‐lab, MarvinSketch, ADMET Predictor and PreADMET). ACD/I‐LAB returned the most accurate values for log D7.4 and plasma protein binding while ADMET Predictor returned the most accurate values for pKa. Large variations in predictive errors were observed between compounds. Experimental values are currently preferable and desirable as they may aid with the future ‘training’ of predictive models for these new psychoactive substances

Recent developments in skin mimic systems to predict transdermal permeation

In recent years there has been a drive to create experimental techniques that can facilitate the accurate and precise prediction of transdermal permeation without the use of in vivo studies. This review considers why permeation data is essential, provides a brief summary as to how skin acts as a natural barrier to permeation and discusses why in vivo studies are undesirable. This is followed by an in-depth discussion on the extensive range of alternative methods that have been developed in recent years. All of the major ‘skin mimic systems’ are considered including: in vitro models using synthetic membranes, mathematical models including quantitative structure-permeability relationships (QSPRs), human skin equivalents and chromatographic based methods. All of these model based systems are ideally trying to achieve the same end-point, namely a reliable in vitro-in vivo correlation, i.e. matching non-in vivo obtained data with that from human clinical trials. It is only by achieving this aim, that any new method of obtaining permeation data can be acknowledged as a potential replacement for animal studies, for the determination of transdermal permeation. In this review the relevance, and potential applicability, of the various model systems will also be discussed

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines

The illicit market for new psychoactive substances is forever expanding. Benzodiazepines and their derivatives are one of a number of groups of these substances and thus far their number has grown year upon year. For both forensic and clinical purposes it is important to be able to rapidly understand these emerging substances. However as a consequence of the illicit nature of these compounds, there is a deficiency in the pharmacological data available for these ‘new’ benzodiazepines. In order to further understand the pharmacology of ‘new’ benzodiazepines we utilised a quantitative structure-activity relationship (QSAR) approach. A set of 69 benzodiazepine-based compounds was analysed to develop a QSAR training set with respect to published binding values to GABAA receptors. The QSAR model returned an R2 value of 0.90. The most influential factors were found to be the positioning of two H-bond acceptors, two aromatic rings and a hydrophobic group. A test set of nine random compounds was then selected for internal validation to determine the predictive ability of the model and gave an R2 value of 0.86 when comparing the binding values with their experimental data. The QSAR model was then used to predict the binding for 22 benzodiazepines that are classed as new psychoactive substances. This model will allow rapid prediction of the binding activity of emerging benzodiazepines in a rapid and economic way, compared with lengthy and expensive in vitro/in vivo analysis. This will enable forensic chemists and toxicologists to better understand both recently developed compounds and prediction of substances likely to emerge in the future

Junior Recital, Cetch Waters, trumpet

The presentation of this junior recital will fulfill in part the requirements for the Bachelor of Music degree in Music Education. Cetch Waters studies trumpet with Dr. Rex Richardson